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Pregabalin is a medication used for the treatment of anxiety, epilepsy and fibromyalgia. Also known by the popular brand name Lyrica, this medication is also used to provide relief from nerve pain caused by diabetes, shingles or spinal injury.
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Important information about Pregabalin
Pregabalin is a prescription medicine used to treat nerve pain, epilepsy and generalised anxiety disorder in adults.
It can cause dizziness and sleepiness and, in some people, can lead to dependence and withdrawal symptoms. It is important to take pregabalin exactly as prescribed. (nhs.uk)
A 300 mg capsule does not mean that 300 mg is the correct dose for everyone.
Pregabalin affects the way certain signals are transmitted in the nervous system.
It is prescribed for:
Pregabalin is available in several strengths, including 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg and 300 mg capsules. (nhs.uk)
Pregabalin 300 mg is one of the available capsule strengths.
The usual total daily dose of standard Pregabalin capsules is between 150 mg and 600 mg per day, divided into two or three doses. The correct dose is determined by a healthcare professional. (nhs.uk)
For some conditions, treatment starts at a lower dose and is gradually increased according to response and side effects.
Do not start with 300 mg, increase your dose or take additional capsules unless this has been specifically prescribed for you.
People with reduced kidney function may require a lower dose.
Pregabalin capsules should be taken exactly as prescribed.
They can normally be taken with or without food.
Try to take doses at approximately the same times each day.
Do not take two doses together to make up for a missed dose. (nhs.uk)
Common side effects include:
Many side effects are mild and may improve as the body becomes accustomed to the medicine. (nhs.uk)
If side effects are severe, persistent or worrying, speak to your doctor or pharmacist.
Serious reactions are uncommon, but they can occur.
Seek urgent medical attention if you experience:
Call 999 if someone has severe difficulty breathing, loses consciousness or cannot be woken. (nhs.uk)
Pregabalin has been associated with severe respiratory depression in some people.
The risk may be higher in people who:
Seek urgent medical help if you develop new or worsening breathing difficulties, particularly if accompanied by extreme sleepiness. (Medicines.org.uk)
Extra caution is required when pregabalin is taken with opioid medicines such as:
Combining pregabalin with opioids can increase central nervous system depression and the risk of serious breathing problems. (nhs.uk)
Always tell your doctor or pharmacist if you take opioid medicines.
It is best to avoid alcohol while taking pregabalin.
Alcohol can increase sleepiness and dizziness, impair concentration and may affect breathing. (nhs.uk)
The risk can be greater when alcohol is combined with other medicines that cause sedation.
Pregabalin can cause:
Do not drive, cycle or operate machinery if pregabalin is affecting your ability to do so safely. (nhs.uk)
Pregabalin can cause dependence and addiction, including when taken at therapeutic doses.
The risk can be higher in people with a current or previous history of substance misuse or certain mental health conditions. (Medicines.org.uk)
Warning signs can include:
If you are concerned about dependence, speak to your doctor or pharmacist.
Do not stop pregabalin suddenly.
Withdrawal symptoms can occur after both short-term and long-term treatment.
Possible symptoms include:
Your doctor can create an individual reduction plan. UK prescribing information recommends gradual withdrawal rather than abrupt discontinuation. (Medicines.org.uk)
Pregabalin is not normally recommended during pregnancy unless a doctor considers the benefits to outweigh the potential risks.
Some studies have found a possible increased risk of birth defects following exposure during pregnancy. (nhs.uk)
If you are:
speak to your doctor.
Do not stop Pregabalin suddenly if you become pregnant.
The NHS recommends effective contraception while taking Pregabalin. Women who are trying to become pregnant or who become pregnant while taking it are advised to discuss treatment with their doctor. High-dose folic acid may also be recommended. (nhs.uk)
Pregabalin passes into breast milk in small amounts.
Current NHS guidance states that a healthy baby can usually be breastfed while the mother takes pregabalin, but this should first be discussed with a doctor or pharmacist. (nhs.uk)
UK product information notes that the effect on newborns and infants is not fully known and that an individual decision should be made about continuing breastfeeding or Pregabalin treatment. (Medicines.org.uk)
If you are breastfeeding, speak to your doctor or pharmacist before changing your medication.
Tell your doctor before taking pregabalin if you:
Pregabalin dosing may need to be adjusted in people with reduced kidney function. (nhs.uk)
Taking more Pregabalin than prescribed can cause serious effects.
Contact NHS 111 if you have taken more than your prescribed dose.
Go to A&E if you have taken too much and become:
Call 999 for severe breathing difficulties or if someone cannot be woken. (nhs.uk)
Take the medicine packet and any other medicines you are taking with you if you need medical attention.
If you forget a dose, follow the instructions provided with your prescription.
Never take two doses together or take an extra dose to make up for a missed dose. (nhs.uk)
If you regularly forget doses, speak to your pharmacist or doctor.
Always tell your doctor or pharmacist about all medicines, supplements and herbal products you take.
Particular caution is required with:
Pregabalin can increase the sedative effects of some medicines. (nhs.uk)
Is 300 mg a high dose?
300 mg is an available capsule strength, but whether it is an appropriate dose depends on the individual and the condition being treated. Standard Pregabalin treatment can range from 150 mg to 600 mg per day, usually divided into two or three doses. (nhs.uk)
Can Pregabalin become addictive?
Yes. Dependence and addiction can occur, including at prescribed doses. (Medicines.org.uk)
Can I drink alcohol with Pregabalin?
It is best to avoid alcohol because it can increase sleepiness, dizziness and potentially affect breathing. (nhs.uk)
Can I drive while taking Pregabalin?
Only if you are able to drive safely and the medicine is not affecting you. Do not drive if you feel sleepy, dizzy, confused, clumsy or have blurred vision. (nhs.uk)
Can I stop Pregabalin suddenly?
No. Sudden discontinuation can cause withdrawal symptoms and, in people taking it for epilepsy, may trigger seizures. A doctor should advise on gradual reduction. (nhs.uk)
Can I take Pregabalin during pregnancy?
Pregabalin may increase the risk of certain birth defects and should only be used during pregnancy when the benefits clearly outweigh the risks. Speak to your doctor. (nhs.uk)
Can I breastfeed while taking Pregabalin?
The NHS says breastfeeding is usually possible if the baby is healthy, but you should discuss it with your doctor or pharmacist first. Pregabalin passes into breast milk in small amounts. (nhs.uk)
Pregabalin is a prescription medicine intended for the person it was prescribed for.
Never give your Pregabalin to another person or take someone else’s prescription.
Because Pregabalin can cause dependence and serious sedation or breathing problems, it should only be used under appropriate medical supervision.
This website provides general educational information about pregabalin and is not a substitute for advice from a doctor, pharmacist or other qualified healthcare professional.
Always follow your prescription and the patient information leaflet supplied with your medicine.
If you have questions about your dose, side effects, pregnancy, breastfeeding, interactions, dependence or stopping treatment, speak to a healthcare professional.
In an emergency, call 999. For urgent but non-life-threatening medical advice in England, contact NHS 111.
Medical information should be reviewed regularly because prescribing guidance can change.
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